ALPHA-ENRICH XANTHONE
Highly concentrated Xanthone helps to inhibit your mind, reduce collagen production, antioxidants and maintain youthful skin. Highly concentrated Xanthone has antimicrobial, anti-collagen and antioxidant properties for smooth, youthful skin.
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Alpha-Enrich Xanthone: High-Potency Mangosteen Xanthone Concentrate for Holistic Wellness
Harness the Power of 50% Alpha-Mangostin – A breakthrough mangosteen peel extract delivering superior antioxidant, anti-inflammatory, anti-cancer, and anti-aging benefits.
The Origin of Mangosteen and Its Medicinal Heritage
Hailed as the “Queen of Fruits,” the mangosteen (Garcinia mangostana L.) has been treasured for centuries in Southeast Asia. In traditional medicine, mangosteen’s thick purple rind (pericarp) was dried, ground, and brewed to treat a host of ailments – from skin infections and wounds to dysentery and urinary tract issues. Ancient healers in Thailand, Malaysia, and surrounding regions would apply mangosteen rind poultices to calm inflammation and promote wound healing, while tonics from its peel were given to reduce fevers and gastrointestinal complaints. This rich ethnomedicinal history set the stage for modern science: researchers eventually identified a unique class of compounds in mangosteen’s peel, called xanthones, as the source of many of its healing properties. Over 40 different xanthones have been isolated from mangosteen, with alpha-mangostin being the most abundant and bioactive. Today, we are bridging this ancient wisdom with cutting-edge biotech – Alpha-Enrich Xanthone harnesses mangosteen’s legendary benefits in a concentrated, scientific form.
Product Overview – ZUBB Biotech’s Enriched Xanthone Extract
Alpha-Enrich Xanthone is a high-purity extract of mangosteen peel developed by ZUBB Biotech (Thailand) to provide an exceptionally potent dose of xanthones. Through advanced extraction techniques, ZUBB Biotech isolates and concentrates the key active components from mangosteen pericarp – notably achieving standardized contents of approximately 45–55% alpha-mangostin, 5–9% gamma-mangostin, and 1–2.5% beta-mangostin. This remarkable concentration makes Alpha-Enrich one of the most xanthone-rich ingredients available for commercial use. The extract is presented as a fine yellow powder, 100% derived from natural mangosteen fruit peels with no carriers or fillers. It is offered in both food-grade and cosmetic-grade specifications, enabling versatile application in dietary supplements or skincare products. Each batch is produced under stringent quality controls to ensure consistency in potency and purity. By condensing the equivalent benefits of many whole mangosteens into a small, easy-to-use ingredient, Alpha-Enrich Xanthone allows formulators and brand owners to infuse the “essence” of mangosteen’s wellness properties into their products with reliable, scalable quality.
Benefits – Antioxidant, Anti-Inflammatory, Anti-Cancer, and Anti-Aging Efficacy
Mangosteen’s xanthones are renowned in scientific literature for their multifaceted health benefits. Alpha-Enrich Xanthone delivers these benefits in a concentrated form, making it a powerhouse functional ingredient. Here are the key evidence-backed benefits of its major xanthones:
- Potent Antioxidant: Xanthones like alpha-mangostin are strong antioxidants that neutralize free radicals and protect cells from oxidative damage. Studies show mangosteen peel extracts have higher antioxidant capacity than many other fruits, helping to prevent cellular damage that leads to aging and chronic diseases. By safeguarding skin and body tissues from oxidative stress, Alpha-Enrich Xanthone contributes to healthier aging and radiant skin.
- Anti-Inflammatory Activity: Alpha-mangostin and gamma-mangostin have demonstrated significant anti-inflammatory effects. They inhibit pro-inflammatory enzymes (such as COX-2) and suppress the release of inflammatory mediators like prostaglandin E₂ and nitric oxide. In immune cell studies, these xanthones downregulated cytokines (IL-1β, IL-6, TNF-α) involved in inflammation. Such actions can help reduce chronic inflammation, providing relief in conditions ranging from joint pain to skin irritation.
- Anti-Cancer Properties: Mangosteen xanthones have shown promising anti-cancer and chemopreventive properties in numerous laboratory studies. Alpha-mangostin in particular can induce apoptosis (programmed cell death) in cancer cells and inhibit tumor growth across various cancer types (colon, breast, lung, prostate, skin, and more). For example, research has found alpha-mangostin causes cell cycle arrest and triggers mitochondrial apoptotic pathways in colon and leukemia cancer lines, comparable to some standard chemotherapy agents. While these effects are in preclinical stages, they highlight the potential of Alpha-Enrich Xanthone as an ingredient for oncology-support supplements or wellness products aimed at cellular health.
- Anti-Aging & Skin Health: By combining antioxidant and anti-inflammatory actions, Alpha-Enrich Xanthone offers notable anti-aging benefits, especially for skin care. The extract inhibits collagen-degrading enzymes (anti-collagenase activity) and protects skin structural proteins from oxidative stress, thereby helping maintain firmness and elasticity. In addition, xanthones have antimicrobial effects against skin pathogens (like Propionibacterium acnes), which can aid in acne control. Users of cosmetics containing mangosteen xanthones have reported smoother, brighter complexions – likely due to reduced inflammation and protection against UV-induced damage. Overall, the bioactives in Alpha-Enrich Xanthone work in synergy to combat the visible signs of aging and promote a youthful, healthy appearance.
These diverse benefits are supported by a growing body of scientific research, making Alpha-Enrich Xanthone an evidence-based ingredient for next-generation wellness products. Each claimed benefit above is rooted in peer-reviewed studies, ensuring that your product’s marketing claims can be backed by credible references (see References section).
Key Benefits – Antioxidant, anti-inflammatory, anti-cancer and anti-aging
What makes Alpha-Enrich Xanthone truly innovative is the technology behind its development. ZUBB Biotech applies state-of-the-art extraction and formulation techniques to maximize the efficacy of mangosteen’s bioactives:
- High-Purity Extraction: Using proprietary solvent extraction and refining processes, ZUBB isolates xanthones from mangosteen peel at exceptionally high purity. By removing excess sugars, tannins, and fibers found in the raw pericarp, they concentrate the most active xanthone compounds. The result is an extract with >50% total xanthones (primarily alpha-mangostin) – far higher than what is found in raw mangosteen fruit or basic powdered peel. This purity ensures strong bioactivity even at small doses.
- Microencapsulation & Nanoemulsion: Recognizing that alpha-mangostin is water-insoluble and can be challenging for the body to absorb, ZUBB Biotech employs advanced delivery technologies to improve bioavailability. The company’s microencapsulation and nano-emulsion techniques can encapsulate xanthones in tiny particles or lipid carriers, enhancing their stability and solubility. For instance, ZUBB’s related product Alpha-Nano Xanthone uses a microcapsule form to increase absorption into the bloodstream and penetration into skin layers. These innovations overcome the traditional limitations of mangosteen extracts (poor solubility and rapid metabolism), thereby unlocking the full therapeutic potential of the xanthones.
- Enhanced Efficacy and Shelf-Stability: The carefully controlled manufacturing process not only concentrates the actives but also preserves their structure and potency. Antioxidants like alpha-mangostin can degrade with heat or light; ZUBB’s technique ensures minimal exposure to degrading conditions, resulting in a stable powder with a long shelf life. Additionally, the optional encapsulation with natural carriers (e.g. maltodextrin, lecithin) provides a protective matrix that shields the xanthones from oxidation and enhances their release profile in the body. This means formulators get an ingredient that remains potent throughout product shelf life and delivers actives more effectively to the consumer.
Through these cutting-edge technologies, Alpha-Enrich Xanthone stands out as a next-generation mangosteen extract – combining the purity of a standardized herbal extract with the performance of pharmaceutical delivery systems. This gives product developers a unique advantage: high efficacy at low inclusion rates, and flexibility to use the ingredient in various product formats without solubility or stability issues.
Application Forms – Versatile Use in Supplements and Cosmetics
One of the greatest strengths of Alpha-Enrich Xanthone is its versatility. This concentrated extract is designed for easy incorporation into a wide range of product types, allowing brands to innovate across the supplement and personal care markets:
- Nutritional Supplements: Alpha-Enrich Xanthone can be formulated into capsules and tablets as a standalone antioxidant or as part of a multi-ingredient wellness formula. Its fine powder form also blends well into powder drink mixes or effervescent tablets, enabling functional beverages that deliver mangosteen’s benefits. Innovative formats like chewable gummies, jellies, or sachet powders are also possible, given the low effective dose (on the order of tens of milligrams). In fact, a daily serving of only about 50–100 mg of Alpha-Enrich Xanthone is typically sufficient to impart significant antioxidant and anti-inflammatory effects. This small required dose means it won’t bulk out your capsules or affect the taste of drinks, yet provides a potent functional boost.
- Cosmetic and Personal Care Products: In cosmetics, Alpha-Enrich Xanthone serves as a high-performance active ingredient for skin health. It is ideal for facial serums, anti-aging creams, lotions, and essence gels, where it can help protect the skin from oxidative damage, calm inflammation, and brighten the complexion. The extract is oil-soluble, and thanks to ZUBB’s formulation options, it can be delivered in either emulsions or encapsulated form for easy mixing into cosmetic bases. Common use levels range around 0.5–0.85% in a formulation for noticeable efficacy without stability issues. Additionally, Alpha-Enrich Xanthone can be integrated into innovative skincare formats like sheet masks, ampoules, or even acne spot treatments, capitalizing on its antimicrobial and soothing properties. Beyond skin care, supplement brands can also incorporate it into nutricosmetics (beauty-from-within supplements) to offer synergistic benefits for skin and overall wellness.
Whether you are formulating a cutting-edge dietary supplement or a premium natural skincare line, Alpha-Enrich Xanthone provides a flexible and powerful ingredient solution. Its neutral taste and odor make it user-friendly in foods and drinks, and its high heat stability allows it to withstand standard cosmetic manufacturing processes. This versatility means you can create an entire product range – from capsules to creams – centered around the revered benefits of mangosteen.
Safety & Certificates – Quality Assurance and Regulatory Compliance
ZUBB Biotech upholds the highest quality and safety standards in producing Alpha-Enrich Xanthone. The ingredient meets rigorous criteria to ensure it is safe, clean, and compliant for use in both foods and cosmetics:
- Clean Label & Natural Origin: Alpha-Enrich is a 100% natural extract from mangosteen peel, with no synthetic additives. It carries a “clean label” profile – meaning it’s free of alcohol, oils, silicones, parabens, added fragrance, or any preservatives. This pure composition is ideal for brands seeking natural or organic product claims.
- Laboratory Tested: Every batch of Alpha-Enrich Xanthone is laboratory-tested for purity and contaminants. The specification guarantees low microbiological counts (<1000 cfu/g total plate count, <1000 cfu/g yeast & mold), ensuring the powder is hygienic and safe. Heavy metals and pesticide residues are tested to be within food-grade limits as well. The xanthone content (alpha, beta, gamma) is verified via HPLC in each batch, so you can be confident the active level on the spec sheet is what you get in your formulation.
- Certifications & Compliance: ZUBB Biotech manufactures this extract under GMP (Good Manufacturing Practice) conditions for both food supplements and cosmetics. The product is made in Thailand and complies with the Thai FDA standards; it can be used in global markets with appropriate regulatory review (mangosteen is generally recognized in ASEAN traditional medicine and supplement lists). Alpha-Enrich Xanthone is also produced cruelty-free (not tested on animals). If needed, documentation such as a Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), and technical data sheet are available to support your product registrations. Moreover, mangosteen has a history of safe use – toxicological studies classify mangosteen peel extracts as non-toxic at usual doses, with one animal study showing no toxicity up to 5000 mg/kg. Human trials of mangosteen products have also reported good safety and tolerance. This strong safety profile, combined with ZUBB’s quality oversight, means you and your consumers can trust in the ingredient’s integrity.
By choosing Alpha-Enrich Xanthone, you align with a supplier committed to quality from farm to finished product. ZUBB Biotech’s facility sources fresh mangosteen peels, processes them under hygienic conditions, and packages the extract with full traceability. This ensures that your final product will not only be effective but also safe, compliant, and marketable under today’s strict regulatory and consumer expectations.
Call-to-Action – Unlock Innovation with Alpha-Enrich Xanthone
Safety and standards are the top priorities for ZUBB Biotech in producing Alpha-Enrich Xanthone to ensure that manufacturers and consumers are fully confident that this ingredient is safe for consumption and external use with the following guarantees:
- Natural & Clean Label: Alpha-Enrich Xanthone extract is extracted from 100% natural ingredients without any synthetic chemicals added. This product is marked with the symbol “100% Natural” and “Clean Label” on the label, which means that it does not contain any unwanted ingredients such as no silicone, no mineral oil, no synthetic fragrance, no paraben, and no alcohol. This feature is in line with the market trend where consumers are looking for products that are natural and gentle on the skin/health. The fact that Alpha-Enrich Xanthone is a pure natural and clean ingredient will help increase the credibility of your end product.
- Passed safety tests in the laboratory: Every production lot of Alpha-Enrich Xanthone will be randomly analyzed in the lab to check the quality. In terms of microbiological safety, this extract is controlled to have a very low amount of microbial contamination, i.e. Total Bacterial Count (TPC) < 1,000 cfu/g and Yeast/Mold < 1,000 cfu/g, which is in line with the safety standards for food and cosmetic ingredients. In addition, it is tested for heavy metals (e.g. arsenic, lead, mercury, cadmium) and chemical residues. To ensure that there is no contamination exceeding the legal standards. The active ingredient (alpha-mangosteen, etc.) is confirmed by HPLC in every batch to ensure that buyers receive the extract at the actual concentration specified. The analysis report (COA) will be delivered with the product for transparency.
- Production standards and certifications: The production of Alpha-Enrich Xanthone is carried out under the GMP (Good Manufacturing Practice) principles for both food and cosmetic production lines. ZUBB Biotech’s factory has been certified with various standards such as ISO and HACCP related to food safety. The product itself can be registered with the FDA in the food supplement or cosmetic group based on supporting documents provided by the company, such as certificates of origin, safety survey sheets (Safety Data Sheet) and technical data. In addition, this mangosteen extract also has properties that comply with the principle of Cruelty-Free, which is an issue that modern consumers are interested in. In terms of consumer safety, toxicology research indicates that mangosteen peels are very safe when consumed in normal quantities. In an experiment, animals were given mangosteen peel extract in high doses and found that there was no acute toxicity up to a dose of 5,000 mg/kg body weight. (It is classified as Category 5, which is safe). And from human data, clinical studies that had people drink mangosteen juice or eat mangosteen products over a period of several weeks found no serious adverse effects. Mangosteen products are considered safe and well tolerated. Therefore, manufacturers and consumers can be assured of the safety of Alpha-Enrich Xanthone when used as directed and in the appropriate dosage.
By using Alpha-Enrich Xanthone in your products, you are choosing natural ingredients that have undergone rigorous quality and safety checks at every stage. This not only reduces legal and liability risks, but also provides a strong selling point in terms of quality for the product, such as labels such as “100% natural extracts”, “lab-tested”, “no additives” and “not tested on animals”, which meet the needs of modern consumers who care about health and ethics.
Inviting Entrepreneurs – Upgrade Your Products with Mangosteen Innovation
If you are a brand owner, a food supplement formula developer or a cosmetic manufacturer looking for new ingredients to differentiate and add value to your products, Alpha-Enrich Xanthone is an option that should not be overlooked. This ingredient allows you to uniquely integrate the story and benefits of the “Queen of Fruits”, mangosteen, into your products. You will be able to present products that are not only good for your health or skin, but also connect with Asian wisdom and modern research, which consumers both domestically and worldwide are looking for.
We invite partners and product developers to join ZUBB Biotech in creating something new. We are ready to support you every step of the way, whether it is providing additional academic information, providing product samples to test in your formula, or providing technical advice on mixing Alpha-Enrich Xanthone with various product formulas. Our team of experts would like to be a part of your success in developing effective and outstanding products in the market.
Don’t miss the opportunity to use this ultimate mangosteen peel extract to help grow your business. Contact ZUBB Biotech today to learn more, discuss your specific needs or request a special price for ordering raw materials. We are ready to be a partner in bringing the value of Thai mangosteen to your world-class products. Let’s impress consumers together. And take your health and beauty industry to the next level with Alpha-Enrich Xanthone!
References
- Obolskiy, D., Pischel, I., Siriwatanametanon, N., & Heinrich, M. (2009). Garcinia mangostana L.: A phytochemical and pharmacological review. Phytotherapy Research, 23(8), 1047–1065. DOI: 10.1002/ptr.2730
- Ovalle-Magallanes, B., Eugenio-Pérez, D., & Pedraza-Chaverri, J. (2017). Medicinal properties of mangosteen (Garcinia mangostana L.): A comprehensive update. Food and Chemical Toxicology, 109, 102–122. DOI: 10.1016/j.fct.2017.08.021
- Gunter, N. V., Teh, S. S., Lim, Y. M., & Mah, S. H. (2020). Natural Xanthones and Skin Inflammatory Diseases: Multitargeting Mechanisms of Action and Potential Application. Frontiers in Pharmacology, 11:594202. DOI: 10.3389/fphar.2020.594202
- Nauman, M. C., & Johnson, J. J. (2022). The purple mangosteen (Garcinia mangostana): Defining the anticancer potential of selected xanthones. Pharmacological Research, 175, 106032. DOI: 10.1016/j.phrs.2021.106032
- Wathoni, N., Meylina, L., Rusdin, A., et al. (2021). The potential cytotoxic activity enhancement of α-mangostin in chitosan–κ-carrageenan-loaded nanoparticles against MCF-7 breast cancer cells. Polymers, 13(10), 1681. DOI: 10.3390/polym13101681
