ALPHA-NANO XANTHONE
Microencapsulated xanthones from mangosteen peel that enhance absorption and protect the skin, providing anti-inflammatory, and brightening benefits.
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Alpha-Nano XANTHONE – Microencapsulated Mangosteen Peel Extract for Enhanced Absorption and Stability
An innovative “xanthone” extract from mangosteen peel in a microencapsulated format—easy to absorb and highly stable—for superior health and beauty applications.
From Traditional Wisdom to Modern Technology
Mangosteen (Garcinia mangostana), known as the “Queen of Fruits” in Thailand, has long been prized for both its flavor and medicinal properties. In traditional Thai medicine, mangosteen peel has been used as a folk remedy to address diarrhea, dysentery, abdominal pain, and infected, purulent, or chronic wounds. This heritage is now supported by science: researchers have identified mangosteen peel as a rich source of xanthones—polyphenolic compounds with multiple bioactivities. Studies on mangosteen peel extracts report antioxidant, anti-inflammatory, antibacterial, antiviral, antiallergic, and—in certain models—anticancer properties, aligning remarkably with historical use.
Notably, the inedible peel—about 69% of the fruit’s weight—contains far higher concentrations of bioactives than the edible arils. Research indicates the peel has up to 10× the total polyphenols (including xanthones, anthocyanins, and tannins) and 20× the antioxidant capacity of the edible pulp. Scientists have identified 50–60 distinct xanthones in mangosteen peel (with alpha-, beta-, and gamma-mangostin among the most studied), and these compounds are recognized as key drivers of mangosteen’s bioactivity.
Leveraging today’s technology, ZUBB Biotech has transformed the value of this Thai botanical into a modern innovation: Alpha-Nano XANTHONE, a microencapsulated mangosteen peel xanthone extract engineered to maximize absorption and stability. It merges traditional knowledge with advanced processing to deliver a high-performance ingredient for contemporary health and beauty formulations.
What is Alpha-Nano XANTHONE?
Alpha-Nano XANTHONE is a commercially ready active developed by ZUBB Biotech. It is a Microencapsulated Xanthone from dried mangosteen peel, enclosed with food-grade wall materials to form fine, micron-scale powder particles. This approach makes the powder water-dispersible, convenient to formulate, and—critically—preserves xanthone integrity better than conventional extracts.
Key Value Propositions
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Enhanced xanthone absorption: Natural xanthones have poor water solubility and limited uptake. The microencapsulated format improves aqueous dispersibility and facilitates permeation across the gastrointestinal tract or skin. Orally, it enables markedly higher uptake versus crude peel powders.
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High stability & longer shelf life: The encapsulating wall acts as a protective barrier against oxygen, light, heat, and moisture—reducing oxidation and degradation. Finished products containing Alpha-Nano XANTHONE maintain potency throughout shelf life.
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Lower use levels with equal or better results: Improved bioavailability means formulators can achieve target performance with less active—helping optimize cost-in-use and minimize off-taste/odor typical of botanicals, while supporting appropriate dosing.
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Dual-market versatility: Available in Food Grade (ingestible) and Cosmetic Grade (topical), the ingredient suits capsules, drink mixes, jellies, as well as serums and creams—addressing both health and beauty markets with one hero active.
Stand-Out Benefits of Alpha-Nano XANTHONE
Alpha-Nano XANTHONE delivers a broad benefit profile derived from natural xanthones—and amplified by microencapsulation.
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Powerful antioxidant activity: Xanthones, particularly alpha-mangostin, are well known for high antioxidant capacity, helping neutralize free radicals that contribute to cellular and skin aging. This supports protection against oxidative stress and the visible signs of aging and Gentle skin turnover support
- Anti-inflammatory action: Xanthones modulate inflammatory mediators, helping reduce redness, swelling, discomfort, and irritation in inflamed skin (e.g., acne lesions, rashes). Users often perceive faster soothing when formulations include Alpha-Nano XANTHONE.
- Antimicrobial support & skin microbiome balance: Historically recognized for antiseptic use, mangosteen peel xanthones inhibit various pathogens, including acne-associated bacteria (Propionibacterium acnes), selected gastrointestinal bacteria, and certain fungi. In topical formats, this can help curb bacterial accumulation on skin—useful for acne-prone care.
- Brighter, more even-toned skin: Research indicates alpha-mangostin can inhibit tyrosinase, a key enzyme in melanin synthesis—supporting diminished hyperpigmentation and a more even complexion. Xanthones also help protect collagen (anti-collagenase), and their strong antioxidant effect further defends against photoaging and pollution, contributing to a youthful, healthy look with regular use.
- Improved uptake and effectiveness: Microencapsulation increases bioavailability, enabling effective outcomes at lower doses. Studies on micro or nano-sized actives show improved solubility, permeation, and delivery, along with reduced degradation in biological environments—unlocking the full potential of xanthones.
Technology Highlight: Microencapsulation for Absorption & Stability
Conventional intake (e.g., crude peel powders or beverages containing peel) yields limited release and absorption; only a small fraction of the total xanthones may be liberated and absorbed during digestion. Meanwhile, these antioxidants are prone to oxidation and degradation under air, light, heat, or humidity.
Microencapsulation “packages” the xanthones within protective micro-scale capsules. Using safe, food-grade polysaccharide wall materials with good water solubility, neutral taste, and clean sensory, the process typically involves preparing a fine emulsion of mangosteen extract followed by spray drying to obtain stable microcapsules.
Functional advantages include:
- Protection against degradation: Capsule walls shield the xanthone payload from oxygen, UV, moisture, and heat—preserving potency from production to end use.
- Controlled release: Systems can be engineered to release actives in preferred environments (e.g., intestinal release for oral formats) or to provide sustained topical delivery for longer-lasting skin benefits with reduced irritation risk.
- Better dispersibility & absorption: With appropriate carriers (e.g., maltodextrin) and emulsifiers, microcapsules disperse efficiently in water/biological fluids, improving permeation across intestinal or skin barriers. Encapsulation can also protect the actives from early degradation (e.g., gastric acid or cutaneous enzymes).
- Lower required dose & improved safety/tolerability: Higher delivery efficiency allows reduced inclusion rates while achieving the same or better outcomes—supporting cost control and sensory improvements (less bitterness/astringency), and decreasing the likelihood of side effects.
Applications: Formats & Market Trends
Thanks to its versatile, water-dispersible powder format, Alpha-Nano XANTHONE is well suited to a wide range of beauty and wellness products.
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Cosmetics & Skincare (Cosmetic Grade)
Ideal for:
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Dark-spot/brightening serums: Combine with vitamin C or niacinamide to reinforce tone-evening benefits.
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Blemish-prone skincare: Creams or gels supporting calmer, clearer-looking skin.
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Toners/essences: Soothing formulas to reduce post-blemish redness and help defend against premature aging.
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Body lotions for overall brightening and skin clarity.
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Sunscreens for added antioxidant support.
Because delivery is efficient, lower inclusion levels are often sufficient—helping manage costs and reduce irritation risk. The ingredient aligns with clean beauty preferences due to its natural origin and avoidance of restricted substances—appealing to both younger consumers seeking novel botanicals and more mature users who value research-backed actives.
“Beauty from Within”
Consumers increasingly seek integrated inner-outer solutions. Alpha-Nano XANTHONE enables cohesive brand storytelling across dietary supplements and topical skincare—for example, pairing a brightening serum with an antioxidant supplement to support comprehensive skin well-being.
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Safety & Standards
Beyond performance, Alpha-Nano XANTHONE meets stringent quality and safety expectations.
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Premium Herbal Extract Credentials: Natural Extract; SLS-Free; Alcohol-Free; Silicone-Free; Fragrance-Free.
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Naturally derived, safe composition: Made from 100% natural materials deemed safe for consumption (GRAS). No hazardous synthetic chemicals and no residual solvents. Compliant with clean-label expectations—no alcohol, parabens, mineral oil, synthetic fragrance, or silicones—suitable for sensitive users in both supplement and cosmetic formats.
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Cruelty-free: Developed without animal testing, supporting brands committed to ethical, cruelty-free practices and strengthening consumer trust.
A New Option for Health & Beauty Product Development
If you are seeking a high-quality, differentiating active, Alpha-Nano XANTHONE offers a compelling balance of Thai herbal heritage and advanced technology. Products built around this ingredient have a strong story, clear performance points supported by research, and relevance across diverse consumer segments.
Whether creating next-generation supplements with tangible outcomes (e.g., anti-aging and calming support capsules or skin-beauty beverages) or skincare with a distinctive, research-forward active, Alpha-Nano XANTHONE is a strategic choice—combining efficacy and safety to win consumer confidence.
| ข้อมูล | รายละเอียด |
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| Trade Name (ชื่อการค้า) | Alpha-Nano XANTHONE |
| Origin (แหล่งที่มา) | Enriched Xanthone in Microcapsule |
| Scientific Name | Garcinia mangostana L. |
| INCI Name | Garcinia Mangostana Peel Extract |
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| ข้อมูลอื่น ๆ (Other information) | – |
รายการอ้างอิง
- Pedraza-Chaverri, J. et al. (2008). Medicinal properties of mangosteen (Garcinia mangostana). Food Chem. Toxicol., 46(10), 3227–3239. DOI: 10.1016/j.fct.2008.07.024
- Kusmayadi, A. et al. (2019). Microencapsulation of mangosteen peel extract with maltodextrin: formulation and characterization. J. Appl. Pharm. Sci., 9(3), 033–040. DOI: 10.7324/JAPS.2019.90306
- Chitchumroonchokchai, C. et al. (2012). Xanthones in mangosteen juice are absorbed and partially conjugated by healthy adults. J. Nutr., 142(4), 675–680. DOI: 10.3945/jn.111.156992
- Inbaraj, B. S., & Chen, B. H. (2023). Quantification of Xanthone and Anthocyanin in Mangosteen Peel by UPLC-MS/MS and Preparation of Nanoemulsions for Studying Their Inhibition Effects on Liver Cancer Cells. Foods, 12(5), 986. DOI: 10.3390/foods12050986
- Zhou, S. et al. (2021). α-Mangostin suppressed melanogenesis in B16F10 murine melanoma cells through GSK3β and ERK signaling pathway. Biochem. Biophys. Rep., 26, 100949. DOI: 10.1016/j.bbrep.2021.100949
