{"id":765,"date":"2025-02-12T11:03:22","date_gmt":"2025-02-12T04:03:22","guid":{"rendered":"https:\/\/zubbbiotech.com\/?post_type=product&p=765"},"modified":"2025-08-26T13:37:02","modified_gmt":"2025-08-26T06:37:02","slug":"alpha-nano-xanthone","status":"publish","type":"product","link":"https:\/\/zubbbiotech.com\/en\/product\/alpha-nano-xanthone\/","title":{"rendered":"ALPHA-NANO XANTHONE"},"content":{"rendered":"

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Alpha-Nano XANTHONE \u2013 Microencapsulated Mangosteen Peel Extract for Enhanced Absorption and Stability<\/strong><\/h2>\n\t\t<\/div>\n\t\t\t\t
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An innovative \u201cxanthone\u201d extract from mangosteen peel in a microencapsulated format\u2014easy to absorb and highly stable\u2014for superior health and beauty applications.<\/p>\n\t\t<\/div>\n\t\t\t\t

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From Traditional Wisdom to Modern Technology<\/strong><\/h3>\n\t\t<\/div>\n\t\t\t\t
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Mangosteen (Garcinia mangostana<\/em>), known as the \u201cQueen of Fruits\u201d in Thailand, has long been prized for both its flavor and medicinal properties. In traditional Thai medicine, mangosteen peel has been used as a folk remedy to address diarrhea, dysentery, abdominal pain, and infected, purulent, or chronic wounds. This heritage is now supported by science: researchers have identified mangosteen peel as a rich source of xanthones<\/strong>\u2014polyphenolic compounds with multiple bioactivities. Studies on mangosteen peel extracts report antioxidant, anti-inflammatory, antibacterial, antiviral, antiallergic, and\u2014in certain models\u2014anticancer properties, aligning remarkably with historical use.<\/p>\n\t\t<\/div>\n\t\t[vc_row_inner][vc_column_inner width=”1\/4″]\t\t

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Notably, the inedible peel\u2014about 69%<\/strong> of the fruit\u2019s weight\u2014contains far higher concentrations of bioactives than the edible arils. Research indicates the peel has up to 10\u00d7<\/strong> the total polyphenols (including xanthones, anthocyanins, and tannins) and 20\u00d7<\/strong> the antioxidant capacity of the edible pulp. Scientists have identified 50\u201360<\/strong> distinct xanthones in mangosteen peel (with alpha-, beta-, and gamma-mangostin among the most studied), and these compounds are recognized as key drivers of mangosteen\u2019s bioactivity.<\/p>\n\t\t<\/div>\n\t\t[\/vc_column_inner][\/vc_row_inner]\t\t

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Leveraging today\u2019s technology, ZUBB Biotech has transformed the value of this Thai botanical into a modern innovation: Alpha-Nano XANTHONE<\/strong>, a microencapsulated mangosteen peel xanthone extract<\/strong> engineered to maximize absorption and stability. It merges traditional knowledge with advanced processing to deliver a high-performance ingredient for contemporary health and beauty formulations.<\/p>\n\t\t<\/div>\n\t\t[vc_separator]\t\t

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What is Alpha-Nano XANTHONE?<\/strong><\/h3>\n\t\t<\/div>\n\t\t\t\t
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Alpha-Nano XANTHONE<\/strong> is a commercially ready active developed by ZUBB Biotech. It is a Microencapsulated Xanthone<\/strong> from dried mangosteen peel, enclosed with food-grade wall materials to form fine, micron-scale powder particles. This approach makes the powder water-dispersible<\/strong>, convenient to formulate, and\u2014critically\u2014preserves xanthone integrity better than conventional extracts.<\/p>\n\t\t<\/div>\n\t\t\t\t

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Key Value Propositions<\/strong><\/h4>\n\t\t<\/div>\n\t\t\t\t
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    Enhanced xanthone absorption:<\/strong> Natural xanthones have poor water solubility and limited uptake. The microencapsulated format improves aqueous dispersibility and facilitates permeation across the gastrointestinal tract or skin. Orally, it enables markedly higher uptake versus crude peel powders.<\/p>\n<\/li>\n

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    High stability & longer shelf life:<\/strong> The encapsulating wall acts as a protective barrier against oxygen, light, heat, and moisture\u2014reducing oxidation and degradation. Finished products containing Alpha-Nano XANTHONE maintain potency throughout shelf life.<\/p>\n<\/li>\n

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    Lower use levels with equal or better results:<\/strong> Improved bioavailability means formulators can achieve target performance with less<\/strong> active\u2014helping optimize cost-in-use and minimize off-taste\/odor typical of botanicals, while supporting appropriate dosing.<\/p>\n<\/li>\n

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    Dual-market versatility:<\/strong> Available in Food Grade<\/strong> (ingestible) and Cosmetic Grade<\/strong> (topical), the ingredient suits capsules, drink mixes, jellies, as well as serums and creams\u2014addressing both health and beauty markets with one hero active.<\/p>\n<\/li>\n<\/ul>\n\t\t<\/div>\n\t\t[vc_separator]\t\t

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    Stand-Out Benefits of Alpha-Nano XANTHONE<\/strong><\/h3>\n\t\t<\/div>\n\t\t\t\t
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    Alpha-Nano XANTHONE delivers a broad benefit profile derived from natural xanthones\u2014and amplified by microencapsulation.<\/p>\n\t\t<\/div>\n\t\t[vc_row_inner][vc_column_inner width=”1\/4″]\t\t

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      Powerful antioxidant activity:<\/strong> Xanthones, particularly alpha-mangostin<\/strong>, are well known for high antioxidant capacity, helping neutralize free radicals that contribute to cellular and skin aging. This supports protection against oxidative stress and the visible signs of aging and Gentle skin turnover support<\/strong><\/p>\n<\/li>\n<\/ul>\n\t\t<\/div>\n\t\t[\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner width=”1\/4″]\t\t

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      • Anti-inflammatory action:<\/strong> Xanthones modulate inflammatory mediators, helping reduce redness, swelling, discomfort, and irritation in inflamed skin (e.g., acne lesions, rashes). Users often perceive faster soothing when formulations include Alpha-Nano XANTHONE.<\/li>\n<\/ul>\n\t\t<\/div>\n\t\t[\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner width=”1\/4″]\t\t
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        • Antimicrobial support & skin microbiome balance:<\/strong> Historically recognized for antiseptic use, mangosteen peel xanthones inhibit various pathogens, including acne-associated bacteria (Propionibacterium acnes<\/em>), selected gastrointestinal bacteria, and certain fungi. In topical formats, this can help curb bacterial accumulation on skin\u2014useful for acne-prone care.<\/li>\n<\/ul>\n\t\t<\/div>\n\t\t[\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner width=”1\/4″]\t\t
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          • Brighter, more even-toned skin:<\/strong> Research indicates alpha-mangostin can inhibit tyrosinase<\/strong>, a key enzyme in melanin synthesis\u2014supporting diminished hyperpigmentation and a more even complexion. Xanthones also help protect collagen<\/strong> (anti-collagenase), and their strong antioxidant effect further defends against photoaging and pollution, contributing to a youthful, healthy look with regular use.<\/li>\n<\/ul>\n\t\t<\/div>\n\t\t[\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner width=”1\/4″]\t\t
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            • Improved uptake and effectiveness:<\/strong> Microencapsulation increases bioavailability<\/strong>, enabling effective outcomes at lower doses. Studies on micro or nano-sized actives show improved solubility, permeation, and delivery, along with reduced degradation in biological environments\u2014unlocking the full potential of xanthones.<\/li>\n<\/ul>\n\t\t<\/div>\n\t\t[\/vc_column_inner][\/vc_row_inner][vc_separator]\t\t
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              Technology Highlight: Microencapsulation for Absorption & Stability<\/strong><\/h3>\n\t\t<\/div>\n\t\t\t\t
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              Conventional intake (e.g., crude peel powders or beverages containing peel) yields limited release and absorption; only a small fraction of the total xanthones may be liberated and absorbed during digestion. Meanwhile, these antioxidants are prone to oxidation and degradation under air, light, heat, or humidity.<\/p>\n

              Microencapsulation<\/strong> \u201cpackages\u201d the xanthones within protective micro-scale capsules. Using safe, food-grade polysaccharide wall materials<\/strong> with good water solubility, neutral taste, and clean sensory, the process typically involves preparing a fine emulsion of mangosteen extract followed by spray drying<\/strong> to obtain stable microcapsules.<\/p>\n\t\t<\/div>\n\t\t\t\t

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              Functional advantages include:<\/strong><\/p>\n

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              • Protection against degradation:<\/strong> Capsule walls shield the xanthone payload from oxygen, UV, moisture, and heat\u2014preserving potency from production to end use.<\/li>\n
              • Controlled release:<\/strong> Systems can be engineered to release actives in preferred environments (e.g., intestinal release for oral formats) or to provide sustained topical delivery<\/strong> for longer-lasting skin benefits with reduced irritation risk.<\/li>\n
              • Better dispersibility & absorption:<\/strong> With appropriate carriers (e.g., maltodextrin) and emulsifiers, microcapsules disperse efficiently in water\/biological fluids, improving permeation across intestinal or skin barriers. Encapsulation can also protect the actives from early degradation (e.g., gastric acid or cutaneous enzymes).<\/li>\n
              • Lower required dose & improved safety\/tolerability:<\/strong> Higher delivery efficiency allows reduced inclusion rates while achieving the same or better outcomes\u2014supporting cost control and sensory improvements (less bitterness\/astringency), and decreasing the likelihood of side effects.<\/li>\n
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                Applications: Formats & Market Trends<\/strong><\/h3>\n\t\t<\/div>\n\t\t\t\t
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                Thanks to its versatile, water-dispersible powder format, Alpha-Nano XANTHONE<\/strong> is well suited to a wide range of beauty and wellness products.<\/p>\n\t\t<\/div>\n\t\t\t\t

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                  Cosmetics & Skincare (Cosmetic Grade)<\/h3>\n

                  Ideal for:<\/p>\n

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                    Dark-spot\/brightening serums:<\/strong> Combine with vitamin C or niacinamide to reinforce tone-evening benefits.<\/p>\n<\/li>\n

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                    Blemish-prone skincare:<\/strong> Creams or gels supporting calmer, clearer-looking skin.<\/p>\n<\/li>\n

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                    Toners\/essences:<\/strong> Soothing formulas to reduce post-blemish redness and help defend against premature aging.<\/p>\n<\/li>\n

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                    Body lotions<\/strong> for overall brightening and skin clarity.<\/p>\n<\/li>\n

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                    Sunscreens<\/strong> for added antioxidant support.<\/p>\n<\/li>\n<\/ul>\n

                    Because delivery is efficient, lower inclusion levels<\/strong> are often sufficient\u2014helping manage costs and reduce irritation risk. The ingredient aligns with clean beauty<\/strong> preferences due to its natural origin and avoidance of restricted substances\u2014appealing to both younger consumers seeking novel botanicals and more mature users who value research-backed actives.<\/p>\n

                    \u201cBeauty from Within\u201d<\/h3>\n

                    Consumers increasingly seek integrated inner-outer solutions. Alpha-Nano XANTHONE enables cohesive brand storytelling across dietary supplements<\/strong> and topical skincare<\/strong>\u2014for example, pairing a brightening serum with an antioxidant supplement to support comprehensive skin well-being.<\/p>\n<\/li>\n<\/ul>\n\t\t<\/div>\n\t\t\t\t

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                    Safety & Standards<\/strong><\/h3>\n\t\t<\/div>\n\t\t\t\t
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                    Beyond performance, Alpha-Nano XANTHONE meets stringent quality and safety expectations.<\/p>\n\t\t<\/div>\n\t\t\t\t

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                      Premium Herbal Extract Credentials:<\/strong> Natural Extract; SLS-Free; Alcohol-Free; Silicone-Free; Fragrance-Free.<\/p>\n<\/li>\n

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                      Naturally derived, safe composition:<\/strong> Made from 100% natural<\/strong> materials deemed safe for consumption (GRAS). No hazardous synthetic chemicals and no residual solvents. Compliant with clean-label<\/strong> expectations\u2014no alcohol, parabens, mineral oil, synthetic fragrance, or silicones<\/strong>\u2014suitable for sensitive users in both supplement and cosmetic formats.<\/p>\n<\/li>\n

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                      Cruelty-free:<\/strong> Developed without animal testing, supporting brands committed to ethical, cruelty-free<\/strong> practices and strengthening consumer trust.<\/p>\n<\/li>\n<\/ul>\n\t\t<\/div>\n\t\t[vc_separator]\t\t

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                      A New Option for Health & Beauty Product Development<\/strong><\/h3>\n\t\t<\/div>\n\t\t\t\t
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                      If you are seeking a high-quality, differentiating active, Alpha-Nano XANTHONE<\/strong> offers a compelling balance of Thai herbal heritage<\/strong> and advanced technology<\/strong>. Products built around this ingredient have a strong story, clear performance points supported by research, and relevance across diverse consumer segments.<\/p>\n

                      Whether creating next-generation supplements with tangible outcomes (e.g., anti-aging and calming support capsules or skin-beauty beverages) or skincare with a distinctive, research-forward active, Alpha-Nano XANTHONE is a strategic choice\u2014combining efficacy<\/strong> and safety<\/strong> to win consumer confidence.<\/p>\n\t\t<\/div>\n\t\t[\/vc_tta_section][vc_tta_section i_icon_fontawesome=”fa fa-solid fa-circle-info” add_icon=”true” title=”Information” tab_id=”1754478160747-64bf82b7-c3cc”]\t\t

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                      Trade Name (\u0e0a\u0e37\u0e48\u0e2d\u0e01\u0e32\u0e23\u0e04\u0e49\u0e32)<\/td>\nAlpha-Nano XANTHONE<\/td>\n<\/tr>\n
                      Origin (\u0e41\u0e2b\u0e25\u0e48\u0e07\u0e17\u0e35\u0e48\u0e21\u0e32)<\/td>\nEnriched Xanthone in Microcapsule<\/td>\n<\/tr>\n
                      Scientific Name<\/td>\nGarcinia mangostana<\/em> L.<\/td>\n<\/tr>\n
                      INCI Name<\/td>\nGarcinia Mangostana Peel Extract<\/td>\n<\/tr>\n
                      Grade<\/td>\n\n
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                      • Food-grade<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
                      Key Actives<\/td>\n\n
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                      • Mangosteen peel Powders<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
                      Effective Dose<\/td>\n\n
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                      • Cosmetic <\/span>: 0.5 \u2013 1.5 %<\/span><\/li>\n
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                        Supplement : 300 \u2013 1000 mg\/day <\/span><\/p>\n<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n

                      \u0e02\u0e49\u0e2d\u0e21\u0e39\u0e25\u0e2d\u0e37\u0e48\u0e19 \u0e46 (Other information)<\/td>\n–<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\t\t<\/div>\n\t\t[\/vc_tta_section][\/vc_tta_tabs][\/vc_column][\/vc_row][vc_row][vc_column][\/vc_column][\/vc_row][vc_row el_class=”cta-bottom-width-full” woodmart_css_id=”6862c616ea182″ responsive_spacing=”eyJwYXJhbV90eXBlIjoid29vZG1hcnRfcmVzcG9uc2l2ZV9zcGFjaW5nIiwic2VsZWN0b3JfaWQiOiI2ODYyYzYxNmVhMTgyIiwic2hvcnRjb2RlIjoidmNfcm93IiwiZGF0YSI6eyJ0YWJsZXQiOnt9LCJtb2JpbGUiOnt9fX0=” mobile_bg_img_hidden=”no” tablet_bg_img_hidden=”no” woodmart_parallax=”0″ woodmart_gradient_switch=”no” woodmart_box_shadow=”no” wd_z_index=”no” woodmart_disable_overflow=”0″ row_reverse_mobile=”0″ row_reverse_tablet=”0″][vc_column][vc_cta h2=”Ask for more details” shape=”round” style=”3d” color=”mulled-wine” add_button=”right” btn_title=”Click here” btn_style=”3d” btn_shape=”round” btn_size=”lg” btn_i_icon_fontawesome=”fa fa-solid fa-phone-flip” css=”” btn_add_icon=”true” btn_link=”url:https%3A%2F%2Flin.ee%2FEAoQBYY|target:_blank”] ZUBB Biotech<\/span><\/span><\/strong> \u00a0is ready to be an innovation partner for your brand! <\/span><\/span>
                      We provide a full range of services by a team of experts and experienced researchers, ready to provide advice on formula development and product strategy to meet the specific needs of consumers.[\/vc_cta][\/vc_column][\/vc_row][vc_row][vc_column]\t\t
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                      1. Pedraza-Chaverri, J. <\/span>et al.<\/span><\/i> (2008). <\/span>Medicinal properties of mangosteen (Garcinia mangostana)<\/b>. <\/span>Food Chem. Toxicol.<\/span><\/i>, 46(10), 3227\u20133239. DOI: 10.1016\/j.fct.2008.07.024\u00a0<\/span><\/li>\n
                      2. Kusmayadi, A. <\/span>et al.<\/span><\/i> (2019). <\/span>Microencapsulation of mangosteen peel extract with maltodextrin: formulation and characterization<\/b>. <\/span>J. Appl. Pharm. Sci.<\/span><\/i>, 9(3), 033\u2013040. DOI: 10.7324\/JAPS.2019.90306\u00a0<\/span><\/li>\n
                      3. Chitchumroonchokchai, C. <\/span>et al.<\/span><\/i> (2012). <\/span>Xanthones in mangosteen juice are absorbed and partially conjugated by healthy adults<\/b>. <\/span>J. Nutr.<\/span><\/i>, 142(4), 675\u2013680. DOI: 10.3945\/jn.111.156992\u00a0<\/span><\/li>\n
                      4. Inbaraj, B. S., & Chen, B. H. (2023). <\/span>Quantification of Xanthone and Anthocyanin in Mangosteen Peel by UPLC-MS\/MS and Preparation of Nanoemulsions for Studying Their Inhibition Effects on Liver Cancer Cells<\/b>. <\/span>Foods<\/span><\/i>, 12(5), 986. DOI: 10.3390\/foods12050986\u00a0<\/span><\/li>\n
                      5. Zhou, S. <\/span>et al.<\/span><\/i> (2021). <\/span>\u03b1-Mangostin suppressed melanogenesis in B16F10 murine melanoma cells through GSK3\u03b2 and ERK signaling pathway<\/b>. <\/span>Biochem. Biophys. Rep.<\/span><\/i>, 26, 100949. DOI: 10.1016\/j.bbrep.2021.100949 <\/span><\/li>\n<\/ol>\n\t\t<\/div>\n\t\t[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

                        Microencapsulated xanthones from mangosteen peel that enhance absorption and protect the skin, providing anti-inflammatory, and brightening benefits.<\/p>\n","protected":false},"featured_media":748,"template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false},"product_brand":[],"product_cat":[71,73],"product_tag":[],"class_list":{"0":"post-765","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-cosmetic-grade","7":"product_cat-food-grade","8":"pa_extract-by-peel-en","9":"pa_extract-by-plant-en","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t